منابع مشابه
RBFOX3/NeuN is dispensable for visual function
RBFOX3/NeuN is a neuronal splicing regulator involved in neural circuitry balance, as well as neurogenesis and synaptogenesis. Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is expressed in a layer-specific manner in the retina, which implies a functional role, however, the ro...
متن کاملNeuN, a neuronal specific nuclear protein in vertebrates.
A battery of monoclonal antibodies (mAbs) against brain cell nuclei has been generated by repeated immunizations. One of these, mAb A60, recognizes a vertebrate nervous system- and neuron-specific nuclear protein that we have named NeuN (Neuronal Nuclei). The expression of NeuN is observed in most neuronal cell types throughout the nervous system of adult mice. However, some major cell types ap...
متن کاملDas DNA-Bank-Netzwerk - Eine Struktur für alle Fälle?
The DNA Bank Network comprises four DNA banks of major biological research collections in Germany. A DNA bank is a technically optimized service facility for the storage of documented DNA as well as a new type of collection. Here we present the structure of the network's database system including all specially created, modified and applied software components. The shared web portal facilitates ...
متن کاملRBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function
RBFOX3 mutations are linked to epilepsy and cognitive impairments, but the underlying pathophysiology of these disorders is poorly understood. Here we report replication of human symptoms in a mouse model with disrupted Rbfox3. Rbfox3 knockout mice displayed increased seizure susceptibility and decreased anxiety-related behaviors. Focusing on hippocampal phenotypes, we found Rbfox3 knockout mic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: DMW - Deutsche Medizinische Wochenschrift
سال: 1898
ISSN: 0012-0472,1439-4413
DOI: 10.1055/s-0029-1204484